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KMID : 0390119930330010169
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Journal of Pusan Medical College
1993 Volume.33 No. 1 p.169 ~ p.180
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Regional Cerebral Water Shifts after Permanent Occlusion of the Middle Cerebral Artery in Rabbits
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Abstract
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The effects of calcium antagonist, nimodipine on regional tissue water shift in the brain of rabbits 8 hours after middle cerebral artery occlusion were studied.
@ES The results were as follows:
@EN 1. Physiological parameters, PaO2, PaCO2 and pH were not significantly changed by injection of nimodipine solution during all experiments. However, systolic blood pressure was immediately lowered after injection of nimodipine solution and the
pressure was rapidly returned to basal level within 10 seconds. Thus the pressure was in stable levels.
1. There was not significant difference between water contents of each brain region in bilateral hemispheres in normal group. Also there was not significant difference among each brain region in each hemisphere.
2. In hemisphere of non-lesion side, there as not significant difference among each brain region. However, in lesion side there was the accumulation of water in pyriform region. The infarction region was highly significant accumulation of water
and the
peri-infarction region was significant accumulation of water content.
3. The water content of each brain regions in non-lesion hemisphere was not significantly different in nimodipine-treated group. Water content of each brain region in lesion hemisphere was reduced in nimodipine-treated group, particularly in
pyriform
region. The accumulation of water in infarcted region was highly significantly reduced by nimodipine treatment, and water content in peri-infarction region was significantly reduced by treatment.
It might be suggested that calcium antagonist, nimodipine can protect brain tissue in a model of focal cerebral infarction by directly reducing water entry into ischemic cells.
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